Potato (Solanum tuberosum L.) is considered to be one of the most prominent nongrain food crops throughout the world that can be regarded as most affordable and most accessible food to provide numerous health benefits. Potential role in improving human health is attributed to presence of wide range of phytonutrients in potatoes viz., polyphenols, anthocyanins, carotenoids, ascorbic acid and proteins, vitamins as well as minerals. In India, more than 75% of the potato production is confined to Indo-Gangetic plains due to thermo-sensitivity of the crop. Several reports are available in recent years to develop new cultivars with improved nutritional value as well as nutrient evaluation of existing cultivars. Current status of research on potato phytonutrients particularly antioxidants, minerals and vitamins in relation to human health as well as research carried out on enhancement of these phytonutrients through genetic manipulations has been compiled in this review article.